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Abstract Non-Western and non-native social organizations can play an important role in global health governance in East Africa. This paper analyzes the important role played by the Aga Khan Development Network (AKDN) in global health governance in East Africa. The study shows that AKDN's extensive participation of global health governance in East Africa is not only resulted from a long history of interaction and integration between East Africa and India, but also related to the localization strategy of “de-religionization and secularization”. AKDN integrates actively with local native communities, safeguards the core interests and positions of their staff with the same religion, and cooperates with Western and global organizations. Meanwhile, AKDN is striving persistently for the right to have its say in East Africa. China can learn from AKDN's experience in the following five aspects. We are supposed to work with local communities, promote the participation of Chinese overseas communities, cooperate with global or Western organizations, support the participation of Chinese non-governmental organizations, and efficiently demonstrate achievements with the help of local media. Finally, the case study of AKDN suggests that non-Western and non-native social organizations can play an important role in global health governance and their contribution should be interpreted appropriately. Such experience of localization is also worthy of learning for China.
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